Dr. Dragos Amarie Awarded with a New Patent


Dr. Dragos Amarie

Dr. Amarie and former collaborators were awarded US Patent 9,267,099 on February 23, 2016 which implements a new design for blood capillary fabrication using living cells within a support medium. Under controlled conditions, culture of specialized cells produces viable lumenized capillary networks with natural or pre-determined geometries by manipulating the extra-cellular medium and basement membrane associated with the capillary networks. Since the capillary networks and its substrate are detachable from the supporting substrate, this technique could be useful in tissue engineering applications. In the long run, both the capillary network and its associated extracellular medium have numerous scientific, industrial and medical applications.

In vitro angiogenesis assays employing the forming capillary network play a crucial role in identifying factors involved in vascular development. Such assays are used in drug development as moderate-throughput screens for angiogenesis promoters and inhibitors related to wound healing, age-related macular degeneration, diabetes, cancer, and other diseases.

Posted in Department, Faculty

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