Sarah Zingales

Research Website

Education

• B. S., Chemistry, Auburn University (2005)
• M.S., Organic Chemistry, Georgia State University (2010)
• Ph.D., Organic Chemistry, Georgia State University (2013)

Dr. Zingales received her B.S. degree in chemistry from Auburn University in 2005.  During her time at Auburn, she was a University Honors Scholar, interned with Nektar Therapeutics, and was a supplemental instructor for General and Organic Chemistry.  Her Ph.D. was awarded in 2013 under the direction of Dr. Binghe Wang at Georgia State University where she designed and synthesis small molecule inhibitor of Hypoxia-Inducible Factor 1 (HIF-1). Dr. Zingales joined the chemistry program at Armstrong Atlantic State University in 2013 which post-consolidation is now Georgia Southern University.

Dr. Zingales’ research interests include synthetic organic chemistry, medicinal chemistry, biochemistry, molecular modeling, brewing science, and chemical education. She collaborates with a variety of other scientists on these projects.

Research

• Medicinal Chemistry – Students in the Zingales lab synthesize small libraries of compounds based on natural products and testing their medicinal properties. Currently, we are focused on chalcones and flavonols, secondary metabolites of plants.
• Biochemistry – We are interested in identifying mechanisms-of-actions for drug resistance in bacteria and fungi and developing new assays for how to study them.
• Brewing Science – This project focuses on developing new, inexpensive methods to analyze the components of beer and wine. Currently, we are focused on a colorimetric detection of MBT, the chemical responsible for the skunky flavor of beer.
• Chemical Education – I am interested in assessment of undergraduate curriculum and how students learn organic chemistry.

Teaching – Courses Taught

• Organic Chemistry 1 Lecture and Laboratory
• Organic Chemistry 2 Lecture and Laboratory
• Medicinal Chemistry
• Advanced Polymer Chemistry
• Undergraduate Research
• General Chemistry 1 Lecture and Laboratory
• Nursing Chemistry 2 Lecture and Laboratory

Recent Publications (2015-present)

1. Gremillion, S.; Baird, W.; Durden, A.; Hunter, N.; Zingales, S., Is She Engineered That Way? Gender, not race, of high school students in Georgia explain unequal levels of confidence and interest in STEM disciplines, especially engineering. Under review in Georgia Educational Researcher 10/1/2018
2. Padgett, C.W.; Lynch, W.E.; Sheriff, K.; Dean, R.; Zingales, S., 3-Hydroxy-2-(4-methylphenyl)-4H-chromen-4-one. IUCrData 2018, 3 (8), x181138. DOI:10.1107/S2414314618011380
3. Wang, X.; Wang, G.; Zingales, S.; Zhao, B. Biomaterials Enabled Cell-Free Strategies for Endogenous Bone Regeneration. Tissue Engineering Part B: Reviews, 2018, published online June 13, 2018 DOI:10.1089/ten.TEB.2018.0012
4. Gibson, M.Z.; Nguyen, M.A.; Zingales, S.K., Design, Synthesis, and Evaluation of (2-(Pyridinyl)methylene)-1-tetralone Chalcones for Anticancer and Antimicrobial Activity. Medicinal Chemistry, 2018, 14 (4), 333-343. DOI: 10.2174/1573406413666171020121244 
5. Ke, B.; Chen, H.; Ma, L.; Zingales, S.; Gong, D.; Hu, D.; Du, L.; Li, M. Visualization of mercury(II) accumulation in vivo using bioluminescence imaging with a highly selective probe. Organic and Biomolecular Chemistry, 2018, 16, 2388-2392. DOI:10.1039/c8ob00398j
6. Zingales, S.; Padgett, C. Crystal structure of 2-(4-chlorophenyl)-3-hydroxy-4H-chromen-4-one. IUCrData, 2017, 2 (7), x170996. DOI:10.1107/S2414314617009968
7. Ferguson, J.H.; De los Santos, Z.; Devi, S.N.; Kaluz, S.; Van Meir, E.; Zingales, S.K.; Wang, B., Design and Synthesis of Benzopyran-based Inhibitors of the Hypoxia-Inducible Factor-1 Pathway with Improved Water Solubility. Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32 (1), 992-1001. DOI:10.1080/14756366.2017.1347784
8. Ferguson, J.; De los Santos, Z.A.; Devi, N.; Zingales, S.K.; Van Meir, E.; Wang, B., Examining the Structure-activity Relationship of Benzopyran based Inhibitors of the Hypoxia Inducible Factor-1 Pathway. Bioorganic Medicinal Chemistry Letters, 2017, 27 (8), 1731-1736. DOI:10.1016/j.bmcl.2017.02.073
9. Zingales, S.K.; Moore, M.E., Design and Synthesis of (2-(furanyl)vinyl)-1-tetralone Chalcones as Anticancer Agents. Der Pharma Chemica, 2016, 8 (21), 40-47. ISSN:0975-413X
10. Zingales, S.K.; Moore, M.E.; Goetz, A.; Padgett, C., Crystal structure of (E)-2-[(2-bromo-3-pyridyl)methylidene]-6-methoxy-3,4-dihydronaphthalen-1-one and 3-[(E)-(6-methoxy-3,4-dihydronaphth-2-oylidene)methyl]-1H-pyridin-2-one. Acta Crystallographica E, 2016, E72, 955-958. DOI:10.1107/S2056989016009300
11. Philip, A.K.; Zingales, S. Targeted Delivery of Drugs to Colon. In Drug Delivery: Principles and Applications, 2^nd Edition, Wang, B.; Hu, L.; Siahaan, T., Ed.; John Wiley & Sons: Hoboken, NJ, 2016; pp. 435-450. DOI:10.1002/9781118833322.ch18
12. Zingales, S.K.; Goetz, A.; Futch, J.; Brown, K.; Wallace, M.Z.; Moore, M.E., Synthesis and Spectral Studies of (2-(furanyl)vinyl)-1-tetralone Chalcones. Heterocyclic Letters, 2015, 5 (4), 537-542. ISSN:2230-9632
13. Leng, H.J.; Peng, F.; Zingales, S.; Huang, W.; Wang, B., Zhao, Q.; Zhou, R.; He, G.; Peng, C.; Han, B., Core-Scaffold-Inspired Asymmetric Synthesis of Polysubstituted Chiral Hexahydropyridazines that Potently Inhibit Breast Cancer Cell Proliferation by Inducing Apoptosis. Chemistry – A European Journal, 2015, 21, 18100–18108. DOI:10.1002/chem.201503063
14. Zingales, S.K.; Wallace, M.Z.; Padgett, C., Crystal Structure of (E)-1-(3-chlorophenyl)-3-(3-furyl)prop-2-en-1-one. Acta Crystallographica E, 2015, E71, o707. DOI:10.1107/S2056989015016266
15. Chen, C.; Zingales, S.; Wang, T.; Yuan, M.; Wang, D.; Cai, L.; Jiang, Q., Synthesis and in vitro evaluation of 4-substituted furano[3,2-c] tetrahydroquinolines as potential anti-cancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, 31 (5), 853-858. DOI:10.3109/14756366.2015.1064120

Last updated: 9/13/2021